Clinical Studies Using Monophasic Action Potential

Monophasic action potential duration during programmed electrical stimulation.

UNLABELLED To examine changes in monophasic action potential duration (APD) with a pacing protocol similar to that used during electrophysiological testing, action potentials were recorded in vivo from the left ventricular apical endocardium of 12 normal mongrel dogs. The atrioventricular node was ablated and the dogs paced from the anterior right ventricle at a baseline cycle length of 1000 ms...

Monophasic Action Potential Morphology in the Human Heart

Background. Recent studies examining mechanisms of defibrillation have focused on prolongation of graded cellular response duration during refractory period stimulation. This mechanism assumes that defibrillation shocks interact with ventricular cells during the process of repolarization. Methods and Results. To test this assumption, we examined monophasic action potentials (MAPs) from 171 epis...

New insights into application of cardiac monophasic action potential.

Monophasic action potential (MAP) recording plays an important role in a more direct view of human myocardial electrophysiology under both physiological and pathological conditions. The procedure of MAP measuring can be simply performed using the Seldinger technique, when MAP catheter is inserted through femoral vein into the right ventricle or through femoral artery to the left ventricle. The ...

Prediction of the onset of atrial fibrillation after cardiac surgery using the monophasic action potential.

OBJECTIVE To show that the monophasic action potential (MAP) recorded continuously from human epicardium may be used to predict the imminent onset of atrial fibrillation or flutter (AF) following surgery, thus allowing prophylactic treatment to be started. PATIENTS 22 patients (14 male, 8 female; mean (SD) age 64 (12) years) undergoing aortic valve replacement. SETTING Tertiary referral cen...

Monophasic action potentials in man.